Kevin Mayer, the chief executive of the Chinese-owned video app TikTok, said that he was resigning after the company came under sustained pressure from the Trump administration over its ties to China.

In a note to employees, which The New York Times reviewed, Mayer said that a series of changes to TikTok’s structure prompted him to leave. He did not address the timing of his departure. The app, which is owned by the Chinese internet company ByteDance, has been ordered by the White House to sell its US operations by mid-September.

“In recent weeks, as the political environment has sharply changed, I have done significant reflection on what the corporate structural changes will require, and what it means for the global role I signed up for,” Mayer, 58, wrote in the email. “Against this backdrop, and as we expect to resolve very soon, it is with a heavy heart that I wanted to let you all know that I have decided to leave the company.”

He added that he had signed up for a global role and that leading a global team had been a “big draw” for him.

Mayer’s departure underscores the difficulties facing TikTok as it has become a geopolitical piñata amid worsening US-China tensions. As part of a tough campaign on China, President Trump and other White House officials have said that TikTok poses a national security threat because of its Chinese ownership.

That led to Trump’s signing an executive order on 6 August to block TikTok if ByteDance did not sell the app’s US operations within 45 days. A week later, he issued another executive order giving ByteDance 90 days to close such a deal.

The White House’s moves have pushed ByteDance and TikTok to seek a buyer for its US operations. Microsoft, Oracle, and other bidders have discussed a potential deal, with prices ranging from $20 billion to $50 billion, though talks are fluid, and no deal may be reached.

At the same time, TikTok has pushed back against the Trump administration. On Monday, the company sued the US government, accusing it of depriving it of due process by forcing a sale using an executive order.

In a statement on Wednesday, TikTok said, “We appreciate that the last few months’ political dynamics have significantly changed what the scope of Kevin’s role would be going forward and fully respect his decision.”

Vanessa Pappas, general manager of TikTok in North America, will take over as the company’s interim global head.

The White House did not immediately respond to a request for comment.

Mayer, the top streaming executive at Walt Disney Company, joined TikTok in May as its chief executive. He also gained the title of chief operating officer of ByteDance.

His hiring was part of a shift by TikTok to bring on more American executives as Washington’s scrutiny of the app’s Chinese ownership grew. TikTok also hired more employees in Los Angeles, New York, and more than a dozen other places in the United States to add over 10,000 new jobs in the country.

But things changed drastically shortly after Mayer joined the company, with White House pressure ramping up and signing the executive orders this month.

Officials at TikTok were shocked by the orders, people with knowledge of the situation have said. For months, the company had worked to satisfy the White House by holdings talks to reduce its Chinese ownership and to find a way to store data on its American users in the United States. TikTok has said it currently stores US user data on servers in Virginia and Singapore.

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